A high-performance Python wrapper for htslib designed for rapid VCF and BCF file manipulation. It leverages Cython to provide C-level speed while maintaining a native Python interface for genomic data science.
Tech Stack
CythonBiology & Biotechnology
Why cyvcf2?
• Extremely fast parsing via htslib
• Direct access to VCF attributes
• Low memory footprint
Limitations
• Requires C-compilation environment
• Limited to VCF/BCF formats
• Steep learning curve for Cython internals
3/4/2026
Last Update
76
Forks
46
Issues
MIT
License
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