hifiasm

The premium Open Source alternative to PacBio SMRT Link

🎯 Best for:Researchers building high-quality, phased reference genomes from long-read data.

What is hifiasm?

Replaces standard assemblers for generating haplotype-resolved de novo genome assemblies from HiFi reads. It produces phased assemblies without requiring parental data by utilizing a specialized graph-based approach.

Tech Stack
C++Biology & Biotechnology

Why hifiasm?

  • Haplotype-resolved output
  • Extremely high contiguity
  • Supports Hi-C integration

Limitations

  • High RAM requirements
  • Optimized only for HiFi reads
  • No graphical interface
3/4/2026
Last Update
108
Forks
578
Issues
MIT
License
Financial Leak Detected

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Competitor Cost
-$1,440
/ year (est. based on PacBio SMRT Link)
Self-Hosted
$0
/ year
Team Size10 Users
150+
SAVE 100%

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